Our New Type of ASO - BROTHERS

Mechanism of Action

Conventional chemical modifications of single-stranded ASO (ssASO) do not have a significant impact on the free energy.
=> These thermodynamic relations (= molecular-interactions) remain largely unchanged.

Reducing the free energy of ASO with a complementary strand can significantly change the molecular interaction landscape.
A novel kinetic mechanism utilizing TMSD (Toehold Mediated Strand Displacement) to promote the formation of desired products.

Wide Therapeutic Window Achieved by BROTHERS